Marie-Thérèse CORVOL

Toxicologie, Pharmacologie et Signalisation céllulaire - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06

Fax : +33 (0) 1 42 86 38 68

Dr. Marie-Thérèse CORVOL

INSERM researcher, DR-INSERM
Pharmacology, toxicology, cell signaling of cartilage and intervertebral disc

maite.corvol@-Code a retirer pour éviter le SPAM-parisdescartes.fr
+33 1 42 86 38 71, room P453B

Dr Maïté Corvol, MD, PhD, is a specialist in cartilage pathophysiology. She generated original data regarding:
1. Implications and mode of action of factors controlling the process of endochondral ossification: Growth Hormone (GH)-dependent factors (IGFs), VitaminD.
2. Evidences that Cartilage tissue is a hormone-dependent tissue: Characterization of Estrogen Receptor (ER) expression in human and animal cartilage. Impact of ER at two distinct ages: regulation of skeletal postnatal growth, and oin steoarthritic post menopausal women.
3. Endocrine Disruptors (ED) and bone skeletal: Gestational exposure to ED in rats alters growth plate cartilage differentiation and skeletal bone growth.
4. Characterization of intervertebral disc (IVD) cell phenotype, as chondrocytic cells. Applications to potential cell therapy of IVD.
5. Bioengineering of cartilage.

Main publications 


Corvol MT, Malemud CJ, Sokoloff L. A pituitary growth-promoting factor of articular chondrocytes in monolayer culture.  
Endocrinology 1972 ; 90:262-271.

Corvol Mt, Ulmann A, Garabedian M. Specific Nuclear Uptake Of 24,25-Dihydroxycholecalciferol, A Vitamin D3 Metabolite Biologically Active In Cartilage. Febs Lett 1980 ; 116:273-276.

Dayani N, Corvol Mt, Robel P, Eychenne B, Moncharmont B, Tsagris L, Rappaport R. Estrogen Receptors In Cultured Rabbit Articular Chondrocytes : Influence Of Age. J Steroid Biochem 1988 ; 31:351-356.

Corvol Mt, Carrascosa A, Brauner R, Rappaport. Effect of sex steroid on bone growth, clinical and fundamental approach. In Disorders of human growth. Advances in Research and Treatment. Cassorla FG, Grave GD (eds) Thomas Publisher, Springfield USA 1988, pp283-288.

Poiraudeau S, Monteiro I, Anract P, Blanchard O, Revel M, Corvol M. Phenotypic characteristics of rabbit intervertebral disc cells: comparison with cartilage cells from the same animals. Spine 1999 ; 24: 837-844.

Francois M, Richette P, Rannou F, Tsagris L, Fitting C, Lemay C, Benallaoua M, Tahiri K, Corvol MT. Activation of the PPAR alpha pathway potentiates IL-1Ra production in cytokine-treated chondrocytes. Arthritis Rheum 2006, 54 : 1233-45.

Montembault A, Tahiri K, Korwin-Zmijosvka C, Chevalier X, Corvol MT, Domard A. A material decoy of biological media based on physical chitosan hydrogels : application to cartilage tissue engineering. Biochimie 2006 ;88, 551-64.

Ladet SG, Tahiri K, Montembault AS, Domard AJ, Corvol MT.Multi-membrane chitosan hydrogels as chondrocytic cell bioreactors. Biomaterials. 2011;32(23):5354-64