Toxicologie, Pharmacologie et Signalisation céllulaire - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Ludmila Juricek @-Code a retirer pour éviter le SPAM-
+33 1 42 86 22 14, room P433
Ludmila Juricek, a young PhD graduate from the University Paris Descartes, worked on the roles of the aryl hydrocarbon receptor (AhR) in the structure of myelin in the murine central nervous system during her thesis. Also, during her PhD studies, she taught biochemistry courses at the bachelor’s and master’s degree levels.
After obtaining a bachelor’s degree in life sciences at the University Paris Descartes, Ludmila pursued studies in the field of environmental toxicology for her master’s degree. During these studies she completed an internship in Team 1 (Toxicology, metabolism and signaling) of INSERM UMRS-1124that had as its subject the investigation of the effects of aromatic amines and their acetylated derivatives (alone or in combination with benzo (a) pyrene) on the signaling pathway of the Ah receptor (AhR). Then, she pursued a PhD in the same laboratory on a new topic: neurotoxicology.
The AhR has been studied extensively to elucidate its role in xenobiotic metabolism. Only recently, with the emergence of animal models deficient for this receptor and with the identification of endogenous ligands, was the involvement of the AhR in diverse physiological functions demonstrated. Furthermore, new AhR functions have been revealed bystudies which have shown that AhR orthologs in invertebrates are incapable of binding exogenous ligands that typically bind to mammalian AhRs. In particular, the AhR plays an important role in the nervous system since it is involved in the regulation of dendritic arborization of neurons and in the development of the retinal mosaic in Drosophila. In addition, the AhR is expressed in some GABAergic neurons and it is involved in feeding behavior in the nematode.
Despite these findings, few data are available as to the consequences of invalidation of the AhR on the functioning of the central nervous system in vertebrates. Moreover, our laboratory has shown that AhR KO mice suffer from oculomotor disorders which consist of a horizontal pendular nystagmus horizontal involuntary (Chevallier et al, 2013). Ludmila’s thesis work elucidated the molecular and cellular mechanisms involved in the onset of nystagmus in AhR deficient mice. During her studies, she acquired diverse expertise in cell culture, molecular biology and in animal experimentation through interactions with many collaborators.
Juricek L, Bui LC, Busi F, Pierre S, Guyot E, Lamouri A, Dupret JM, Barouki R, Coumoul X, Rodrigues-Lima F : Arch Toxicol, 2014