Toxicologie, Pharmacologie et Signalisation céllulaire - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Paris Descartes Engineer
Pharmacology, toxicology, cell signaling of cartilage and intervertebral disc
francois.etienne@-Code to remove to avoid SPAM-parisdescartes.fr
+33 1 42 86 38 70, room P452
François Etienne, engineer at the University Paris Descartes, is interested in mechanobiology and more specifically in cellular mechanotransduction. He is the manager of the platform “Mechanical Stress” and associated projects. He also is responsible for the development of projects related to the intervertebral disc.
Specialized in material sciences (University of Rouen), François Etienne has dedicated himself to molecular biophysics since joining the University Paris Descartes as assistant engineer in 1997. He has expertise in the characterization and the determination of the nature of lipid-lipid interactions in biomimetic membranes such as “Langmuir” and multi-lamellar vesicles. He obtained a doctorate in molecular biophysics from the University Paris Descartes in 2005. Wishing to expand his expertise to the field of living organisms by working at the cellular and tissular levels, he joined the team of Prof. François Rannou in 2009 after having obtained an engineer position.
Now Francois Etienne devotes himself entirely to the investigation of cellular mechanotransduction. His activities as manager of the “Mechanical Stress” platform, have led him to develop further this area of research by assisting and directing users in their projects.
These projects focus on the study of the responses to mechanical stress of cells that are derived from diverse tissues: articular chondrocytes, osteocytes, oligodendrocytes. He elaborates the characteristics of the mechanical stress to be applied (the signal form, intensity, frequency and duration) based on the anatomical origin of the sample, the context (physiological, pathological or accidental) and the response to be investigated.
An important part of his activities is devoted to the technical development of the platform, in particular to the development of systems to study the compression of cells that are cultured in 3D matrices and to real-time imaging of cells that are subjected to stretching in 2D culture.
He also ensures the development and monitoring of projects related to the intervertebral disc: collection of samples of human discs that are obtained during surgery (lumbar arthrodesis), investigation of the effect of microgravity on murine discs (CNES project).
Chierto E, Simon A, Castoldi F, Meffre D, Cristinziano G, Sapone F, Carrete A, Borderie D, Etienne F, Rannou F, Morrison B, Massaad C, Jafarian-Tehrani M : Mol Neurobiol, 2018
Moreau D, Chauvet C, Etienne F, Rannou FP, Corté L : Proc Natl Acad Sci U S A, 2016
Petit PX, Dupaigne P, Pariselli F, Gonzalvez F, Etienne F, Rameau C, Bernard S : FEBS J, 2009
Etienne F, Roche Y, Peretti P, Bernard S : Chem Phys Lipids, 2007