Toxicologie, Pharmacologie et Signalisation céllulaire - UMR-S 1124
Université Paris Descartes
45 rue des Saints Pères
75270 Paris Cedex 06
Fax : +33 (0) 1 42 86 38 68
Pr. Caroline CHAUVET
caroline.chauvet@-Code to remove to avoid SPAM-parisdescartes.fr
+33 1 42 86 22 14, room P433
Caroline Chauvet is Assistant Professor of Biochemistry and Molecular Biology (University Paris Descartes) since 2007. Her research is aimed at the identification of new biomarkers and therapeutic targets in several osteoarticular diseases (osteoarthritis, arthritis…) with the use of cell and animal models. She studies the effects of inflammatory and mechanical stresses. She teaches biochemistry and biology in several undergraduate and Master’s Degree programs.
After graduating from the Ecole Normale Supérieure, the University Pierre et Marie Curie in Paris and the University Paris Sud in Orsay with a Master’s Degree in endocrinology, Caroline Chauvet obtained her Ph.D. in Cell and Molecular Biology (2004) following research on the role of the RORa nuclear receptor in the liver and, in particular, on the response of hepatic cells to hypoxia (University Paris Sud). After a post-doctoral fellowship in Canada (Molecular Oncology Group, McGill University, Montreal) during which she studied the role of RORa in the central nervous system, she returned to France as a teaching assistant and became Assistant Professor (University Paris Descartes) in the group directed by Pr. F. Rannou in 2007.
Caroline Chauvet’s research work is directed toward better understanding the processes that take place during the development of osteoarticular diseases (osteoarthritis, arthritis…) by focusing on articular cartilage and the intervertebral disc. She studies the effects of the two main stresses in these diseases which represent a public health issue: mechanical stress and inflammatory stress. Large scale transcriptome analyses of primary cultured chondrocytes submitted or not to a mechanical stress (stretch) or/and to an inflammatory stress identified several targets of these stresses (relaxin, Wnt signaling molecules…). The use of cultured chondrocytes and that of an in vivo model of arthritis (K/BxN mouse) allow the testing of the anti-inflammatory and chondroprotective effects of different molecules such as phospholipases A2 inhibitors, cell signaling molecules and modulators of cell proliferation. These approaches correspond to a first step in the search for biomarkers for and therapeutic targets against osteoarticular diseases.
Moreau D, Chauvet C, Etienne F, Rannou FP, Corté L : Proc Natl Acad Sci U S A, 2016
Bézière N, Decroos C, Mkhitaryan K, Kish E, Richard F, Bigot-Marchand S, Durand S, Cloppet F, Chauvet C, Corvol MT, Rannou F, Xu-Li Y, Mansuy D, Peyrot F, Frapart YM : Mol Imaging, 2012
Ombetta JE, Thelier N, Dong CZ, Plocki S, Tsagris L, Rannou F, Massicot F, Djimdé A, El-Hayek E, Shi Y, Heymans F, Gresh N, Chauvet C : PLoS One, 2010
Tordjman J, Leroyer S, Chauvet G, Quette J, Chauvet C, Tomkiewicz C, Chapron C, Barouki R, Forest C, Aggerbeck M, Antoine B : J Biol Chem, 2007