Team 1 – SIGNALING IN ENVIRONMENTAL AND DRUG TOXICOLOGY

 

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Our team investigates the signaling pathways that are activated by environmental pollutants and, in particular, dioxins, pesticides, alcohol and their mixtures. Our main focus is a transcription factor, the Aryl hydrocarbon Receptor (or AhR), which is activated following its binding to these xenobiotics. This protein triggers the transcription of xenobiotic metabolizing enzymes, which allow the detoxification of the ligands and their elimination from the body. Our work has shown, however, that the AhR regulates many other functions:

1) We have demonstrated, using tumor cell lines, that TCDD (the most well-studied dioxin) stimulates an epithelial-mesenchymal transition which could contribute to pathological processes such as a) tumor metastasis (clinical investigations are underway); b) chronic liver diseases including steatosis and fibrosis (studied with murine models).

2) The mixture TCDD and a-endosulfan alters the expression of enzymes which are involved in the metabolism primarily of carbohydrates, lipids and alcohol. The change in the expression of these enzymes results in a metabolic disruption (ex: Warburg effect) which could be responsible for the previously cited pathological proceesses. At present, we are investigating the effects of such mixtures of pollutants using both proteomic and metabolomic technologies (HEALS European project).

3) Adipose tissue stores and releases hydrophobic pollutants and a significant part of our work is dedicated to the study of the effects of xenobiotics on adipose tissue metabolism.

4) We discovered and continue to investigate the visio-motor abnormalities in AhR knockout mice which are present in the absence of pollutants. These abnormities suggest that the AhR protein plays a role in ocular stability.

5) Diverse functional effects may arise from a structural flexibility in the AhR which permits its binding to diverse ligands. We collaborate with the group of Dr. Pierre Nioche (Crystallography group at the University Paris Descartes) to elucidate the mechanisms by which ligand induced structural alterations in the AhR lead to these diverse functional effects.

Team leader

  • Xavier COUMOUL, University Professor, MetaTox
    xavier.coumoul@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 33 59, room P433

Members

  • Lawrence AGGERBECK, CNRS researcher, DR- CNRS, MetaTox
    lawrence.aggerbeck@-Code a retirer pour éviter le SPAM-parisdescartes.fr , +33 1 42 86 20 73, room P435
  • Chercheur CNRS
    Martine AGGERBECK, CNRS researcher, CR-CNRS, MetaTox
    martine.aggerbeck@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 20 93, room P431
  • Karine ANDRÉAU, lecturer, MetaTox
    karine.andreau@-Code a retirer pour éviter le SPAM-univ-paris-diderot.fr, +33 1 42 86 33 60, room P434
  • Samantha ANTONIO, Paris Descartes Engineer, MetaTox
    samantha.antonio@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 38 65, room P461
  • Eléonore ATTIGNON, Post-doctoral fellow, MetaTox
    eleonore.attignon@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 22 14, room P433
  • Robert BAROUKI, Laboratory Director, MetaTox
    robert.barouki@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 38 66, room P460
  • Anne-Sophie BATS, Associate professor, MCU-PH Paris Descartes, MetaTox
    anne-sophie.bats@-Code a retirer pour éviter le SPAM-egp.aphp.fr
  • Chantal BENELLI, INSERM researcher, CR- INSERM, MetaTox
    chantal.benelli@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 38 65, room P461
  • Etienne BLANC, Lecturer, MetaTox
    etienne.blanc@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 33 60, room P434
  • Sylvie BORTOLI, University researcher, IR, MetaTox
    sylvie.bortoli@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 38 65, room P461
  • Bernadette CHADEFAUX-VEKEMANS, Associate professor, MCU-PH Paris Descartes, MetaTox
    bernadette.chadefaux-vekemans@-Code a retirer pour éviter le SPAM-nck.ap-hop-paris.fr
  • Caroline CHAUVET, Associate Professor, MetaTox
    caroline.chauvet@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 22 14, room P433
  • Emilie DISTEL, Post-doctoral fellow, MetaTox
    Distel Emilie @-Code a retirer pour éviter le SPAM-, +33 1 42 86 38 65, room P461
  • Claude FOREST, INSERM researcher, DR- INSERM, MetaTox
    claude.forest@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 22 21, room R286
  • Ludmila JURICEK, Post-doctoral fellow, MetaTox
    Ludmila Juricek @-Code a retirer pour éviter le SPAM-, +33 1 42 86 22 14, room P433
  • Min-Ji KIM, lecturer, MetaTox
    min-ji.kim@-Code a retirer pour éviter le SPAM-inserm.fr, +33 1 42 86 33 60, room P434
  • Béatrice LE GRAND, Paris Descartes Technician, MetaTox
    beatrice.le-grand@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 33 60, room P434
  • Hélène ROUACH, Professor Emeritus, MetaTox
    helene.rouach@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 22 21, room R286
  • Céline TOMKIEWICZ-RAULET, INSERM Engineer, MetaTox
    Celine.Tomkiewicz-raulet@-Code a retirer pour éviter le SPAM-parisdescartes.fr, +33 1 42 86 20 93, room P431

Main publications

 

Recent Publications

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