Team 2 – PHARMACOLOGY, TOXICOLOGY, CELL SIGNALING OF CARTILAGE AND INTERVERTEBRAL DISC

Team 2 has developed a general expertise in pharmacology, toxicology, cell signaling of cartilage and intervertebral disc and an original expertise in the field of joint diseases such as arthritis, osteoarthritis and scoliosis using specific in vitro models (chondrocytes, synoviocytes) and in vivo animal models. Indeed, in order to deliver specific treatment for intervertebral disc and cartilage diseases, the first step is to better understand the pathogenesis of intervertebral disc and cartilage disorders. The originality of Team 2 is to be directly connected with clinicians from Assistance Publique- Hôpitaux de Paris Hospitals as Team 2 leader (Prof François Rannou) is co-leading the department of Physical Medicine and Rehabilitation of Cochin Hospital, Paris, France. This specificity allows access to human tissues from finely phenotyped patients. Prof Francois Rannou (PU-PH) has an expertise in in vitro experiments, mechanotransduction and clinical evaluation of patients, Dr Francois Étienne (Research Engineer) in animals breeding, primary cell cultures and mechanotranduction, Prof Didier Borderie (PU-PH) in in vitro experiments regarding human synoviocytes, and Dr Christelle Nguyen (CCA-AHU) in development biology and clinical evaluation of patients.

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